A 2018 Land Rover traveling southbound on Highway 29, south of Oak Knoll Avenue, on Sunday night rear-ended a 2015 Honda Pilot with three occupants, the California Highway Patrol reported.
The collision, which occurred at 7:40 p.m., resulted in the driver and the occupant of the Land Rover going to Queen of the Valley Medical Center by ambulance for treatment.
The CHP said the driver, Julie Germenis, 23, of Napa, had a high level of intoxication. She was arrested at the hospital with injuries described as minor.
Her passenger, Jessica Perazzo, 25, of Napa, was taken to the hospital with major injuries, the CHP said.
The Land Rover struck the rear of the Honda Pilot going 60 mph driven by Alvaro Bautista, 43, of Napa, the CHP said.
After the collision, the Land Rover overturned on the highway's west shoulder, the CHP said.
Bautista and his passengers, Alfonso Bautista, 87, and Angelina Bautista, 81, both of Napa, drove themselves to the Queen for treatment of minor injuries, the CHP said.